The Group’s Biotechnology and Biological Sciences Research Council (BBSRC) grant application was successful! Huge congratulations to Sarah Schneider, Almutasem Saleh and Yasunori Noguchi for writing a fantastic proposal and achieving a superb ranking of fourth out of 89. Two new postdoctoral positions will open soon. Interested candidates should contact Christian Speck.
First data collected using the London Consortium for cryo-EM’s (LonCEM’s) new Titan Krios Cryo Transmission Electron Microscope with the Gatan K3™ camera in super-resolution mode. A dream come true.
Noguchi, Y., Yuan, Z., Bai, L., Schneider, S., Zhao, G., Stillman, B., Speck, C., Li, H. (2017). Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. Proceedings of the National Academy of Sciences of the United States of America 114, E9529-E9538.
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As a selected participant, Katalin Kondas attends the EMBO Practical Course “High-throughput protein production and crystallization”, 6 – 14 July 2017 in Harwell, Oxfordshire, UK.
Yuan, Z., Riera, A., Bai, L., Sun, J., Nandi, S., Spanos, C., Chen, Z. A., Barbon, M., Rappsilber, J., Stillman, B., Speck, C., Li, H. (2017). Structural basis of Mcm2–7 replicative helicase loading by ORC–Cdc6 and Cdt1. Nature Structure & Molecular Biology 24, 316-324.
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Henry Gerdes passes his MSc viva with distinction. Congratulations and well done Henry!
Speck, C. (2016). Exceeding the limits – Cdc45 overexpression turns bad. Cell Cycle 15, 1809-1810.
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Tognetti, S., Speck, C. (2016). Replicating repetitive DNA. Nature Cell Biology 18, 593-594.
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Herrera, M. C.*, Tognetti, S.*, Riera, A., Zech, J., Clarke, P., Fernández-Cid, A., Speck, C. (2015). A reconstituted system reveals how activating and inhibitory interactions control DDK dependent assembly of the eukaryotic replicative helicase. Nucleic Acids Research 43, 10238-10250.
*Shared first authorship
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Chang, F., Riera, A., Evrin, C., Sun, J., Li, H., Speck, C., Weinreich, M. (2015). Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication. eLife 4, e05759.
Abstract | Full text | Biomedical Picture of the Day | MRC Clinical Sciences Centre News | Imperial College London News |
Alice Rödel successfully presents her Masters research at the Beuth Hochschule für Technik Berlin, Germany, achieving the highest marks for both the presentation and the written report. Well done Alice!
