SpeckLab – Speck Lab / DNA Replication Group

Feng, X., Noguchi, Y., Barbon, M., Stillman, B., Speck, C., Li, H. (2021). The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nature Communications 12, 3883. Abstract | Full Text |

By SpeckLabLab Group, Publications, ResearchCdc6, DNA replication, cryo-EM, ORC-Cdc6, ORC activation0 CommentsRead more...

06Feb20216 February 2021

New Talos F200i microscope

The Institute got a brand new Thermo Scientific™ Talos™ F200i S/TEM microscope and said goodbye to the Philips CM200. A significant and exciting upgrade!

By SpeckLabEquipmentelectron microscopy, scanning transmission electron microscope, Thermo Scientific Talos F200i S/TEM0 CommentsRead more...

09Nov20209 November 2020

Josh Tomkins joins the Group

Josh Tomkins joined the Group as a PhD student. Welcome Josh!

By SpeckLabLab Group, PeopleJosh Tomkins0 CommentsRead more...

05Oct20205 October 2020

Marina Ivanova and Lepakshi Ranjha join the Group

Marina Ivanova and Lepakshi Ranjha joined the Group as postdoctoral fellows. A big welcome to both!

By SpeckLabLab Group, PeopleLepakshi Ranjha, Marina Ivanova0 CommentsRead more...

15Jul202015 July 2020

New paper on the structural mechanism of helicase loading

Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C. (2020). Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proceedings of the National Academy of Sciences of the United States of America 117, 17747-17756. Abstract | Full Text |

By SpeckLabLab Group, Publications, Researchhelicase loading, DNA replication, origin DNA, cryo-EM, ORC-Cdc60 CommentsRead more...

07Nov20197 November 2019

Group awarded BBSRC project grant

The Group's Biotechnology and Biological Sciences Research Council (BBSRC) grant application was successful! Huge congratulations to Sarah Schneider, Almutasem Saleh and Yasunori Noguchi for writing a fantastic proposal and achieving a superb ranking of fourth out of 89. Two new postdoctoral positions will open soon. Interested candidates should contact Christian Speck.

By SpeckLabLab Group, Research, GrantsBBSRC, Biotechnology and Biological Sciences Research Council0 CommentsRead more...

11Oct201911 October 2019

Data collected using new Titan Krios cryo-TEM

First data collected using the London Consortium for cryo-EM's (LonCEM's) new Titan Krios Cryo Transmission Electron Microscope with the Gatan K3™ camera in super-resolution mode. A dream come true.