Lab Group

VACANCY: Research associate in molecular machines (MED04213)

Reference: MED04213 Date posted: 06 November 2023 Closing date: 03 January 2024 Applications are invited for a full-time postdoctoral research associate position with the aim of uncovering fundamental and medically relevant mechanisms that guarantee efficient human DNA replication employing cutting-edge biochemical and structural approaches.  The project's primary objective is to discover how 1) DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2) DNA replication is regulated to allow faithful DNA replication.  The successful candidate will be able to take advantage of a recently established reconstituted system, which allows us to address these questions for the first time. Job details | Apply

New paper on DDK structure, control and selective activation of the MCM2-7 helicase

Saleh, A., Noguchi, Y., Aramayo, R., Ivanova, M. E., Stevens, K. M., Montoya, A., Sunidhi, S., Carranza, N. L., Skwark, M. J., Speck, C. (2022). The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nature Communication 13:2915. Abstract | Full Text |

New paper on the molecular mechanism in the licensing of eukaryotic replication origins

Feng, X., Noguchi, Y., Barbon, M., Stillman, B., Speck, C., Li, H. (2021). The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nature Communications 12:3883. Abstract | Full Text |

New paper on evolution of DNA replication origin and gene silencing

Hu, Y., Tareen, A., Sheu, Y. J., Ireland, W.T ., Speck, C., Li, H., Joshua-Tor, L., Kinney, J. B., Stillman, B. (2020). Evolution of DNA replication origin specification and gene silencing mechanisms. Nature Communications 11:5175. Abstract | Full Text |