Category: Lab Group

24Aug202424 August 2024

New paper on genome-wide origin licensing

Reuter L. M., Khadayate, S. P., Mossler, A., Liebl, K., Faull, S. V., Karimi, M. M., Speck, C. (2024). MCM2-7 loading-dependent ORC release ensures genome-wide origin licensing. Nature Communications 15: 7306. Full text |

By SpeckLabLab Group, Publications, ResearchORC, MCM2-7, DNA licensingRead more...

08Apr20248 April 2024

Anna Schmidt joins the Group

Anna Schmidt joins the Group as a postdoctoral fellow. Welcome, Anna!

By SpeckLabLab Group, PeopleAnna SchmidtRead more...

15Feb202415 February 2024

Nicholas Sim joins the Group

Nicholas Sim joins the Group as a postdoctoral fellow. Welcome, Nicholas!

By SpeckLabLab Group, PeopleNicholas SimRead more...

04Sep20234 September 2023

New review paper on pre-RNA splicing in metabolic homeostasis and liver disease

Jobbins, A. M., Yu, S., Paterson, H. A. B., Maude, H., Kefala-Stavridi, A., Speck, C., Cebola, I., Vernia, S. (2023). Pre-RNA splicing in metabolic homeostasis and liver disease. Trends in Endocrinology & Metabolism 34, P823-P837. Abstract | Full text |

By SpeckLabLab Group, Publications, Researchalternative RNA splicing, liver, metabolic homeostasis, pre-mRNA splicing, reviewRead more...

03Oct20223 October 2022

Antonia Kefala Stavridi and Anna Schmücker join the Group

Antonia Kefala Stavridi and Anna Schmücker join the Group as postdoctoral fellows. Welcome, Tonia and Anna!

By SpeckLabLab Group, PeopleAntonia Kefala Stavridi, Anna SchmückerRead more...

25May202225 May 2022

New paper on DDK structure, control and selective activation of the MCM2-7 helicase

Saleh, A., Noguchi, Y., Aramayo, R., Ivanova, M. E., Stevens, K. M., Montoya, A., Sunidhi, S., Carranza, N. L., Skwark, M. J., Speck, C. (2022). The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer. Nature Communication 13:2915. Abstract | Full Text |

By SpeckLabLab Group, Publications, ResearchCdc7-Dbf4 kinase, Dbf4, DDK, MCM2-7 phosphorylation, Cdc7-Dbf4, MCM2-7, DNA replication, Cdc7Read more...

25Apr202225 April 2022

Shivni Chauhan joins the Group

Shivni Chauhan joins the Group as a MRes student. Welcome, Shivni!

By SpeckLabLab Group, PeopleShivni ChauhanRead more...

21Mar202221 March 2022

Jennifer Wells joins the Group

Jennifer Wells joins the Group as a postdoctoral fellow. Welcome, Jennifer!

By SpeckLabLab Group, PeopleJennifer WellsRead more...

24Jan202224 January 2022

Lucy Edwardes joins the Group

Lucy Edwardes joins the Group as a PhD student. Welcome, Lucy!

By SpeckLabPeople, Lab GroupLucy EdwardesRead more...

04Oct20214 October 2021

Matthew Peach joins the Group

Matthew Peach joins the group as a PhD student. Welcome, Matt!

By SpeckLabLab Group, PeopleMatthew PeachRead more...

20Aug202120 August 2021

Ki Him Nicholas Chiang joins the Group

Ki Him Nicholas Chiang, a biotechnology undergraduate at Imperial College London, joins the Group as a summer student intern. Welcome, Nick!

By SpeckLabLab Group, PeopleKi Him Nicholas ChiangRead more...

23Jun202123 June 2021

New paper on the molecular mechanism in the licensing of eukaryotic replication origins

Feng, X., Noguchi, Y., Barbon, M., Stillman, B., Speck, C., Li, H. (2021). The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nature Communications 12:3883. Abstract | Full Text |

By SpeckLabLab Group, Publications, ResearchDNA replication, cryo-EM, ORC-Cdc6, ORC activation, Cdc6Read more...