Headed by Christian Speck, the DNA Replication Group was established in 2006 with the aim of discovering new mechanisms in the initiation and elongation of DNA replication and understanding the function of replication factors in hetero-chromatin formation and epigenetic memory.
Group News
New paper on DDK structure, control and selective activation of the MCM2-7 helicase
Saleh, A., Noguchi, Y., Aramayo, R., Ivanova, M. E., Stevens, K. M., Montoya, A., Sunidhi, S., Carranza, N. L., Skwark,... read more
Shivni Chauhan joins the Group
Shivni Chauhan joins the Group as a MRes student. Welcome Shivni! read more
Jennifer Wells joins the Group
Jennifer Wells joins the Group as a postdoctoral fellow. Welcome Jennifer! read more
Lucy Edwardes joins the Group
Lucy Edwardes joins the Group as a PhD student. Welcome Lucy! read more
Matthew Peach joins the Group
Matthew Peach joins the group as a PhD student. Welcome Matt! read more
Ki Him Nicholas Chiang joins the Group
Ki Him Nicholas Chiang, a biotechnology undergraduate at Imperial College London, joins the Group as a summer student intern. Welcome... read more
New paper on the molecular mechanism in the licensing of eukaryotic replication origins
Feng, X., Noguchi, Y., Barbon, M., Stillman, B., Speck, C., Li, H. (2021). The structure of ORC-Cdc6 on an origin... read more
New Talos F200i microscope
The Institute got a brand new Thermo Scientific™ Talos™ F200i S/TEM microscope and said goodbye to the Philips CM200. A... read more
Josh Tomkins joins the Group
Josh Tomkins joined the Group as a PhD student. Welcome Josh! read more
New paper on evolution of DNA replication origin and gene silencing
Hu, Y., Tareen, A., Sheu, Y. J., Ireland, W.T ., Speck, C., Li, H., Joshua-Tor, L., Kinney, J. B., Stillman,... read more
Marina Ivanova and Lepakshi Ranjha join the Group
Marina Ivanova and Lepakshi Ranjha joined the Group as postdoctoral fellows. A big welcome to both! read more
New paper on the structural mechanism of helicase loading
Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H.,... read more
Group Milestones
2020
PNAS 117, 17747-17756
2017
PNAS 114, E9529-E9538
Elucidation of the structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1
Nature Structure & Molecular Biology 24, 316-324
2014
Genes & Development 28, 2291-2303
Identification of the DNA entry gate of the MCM2-7 helicase during helicase loading
Genes & Development 28, 1653-1666
2013
Nature Structural & Molecular Biology 20, 944-951
Identification of a novel ATPase-dependent pre-RC intermediate that is surveyed by a quality control mechanism for genomic stability
Molecular Cell 50, 577-588
Discovery of a pre-RC intermediate that forms in the absence of ATP-hydrolysis and contains one copy of all 18 pre-RC factors
Nucleic Acids Research 41, 3162-3172
2009
PNAS 106, 20240-20245
2007
The Journal of Biological Chemistry 282, 11705-11714
2005
Nature Structural & Molecular Biology 12, 965-971
2001
The EMBO Journal 20, 1469-1476
1999
The EMBO Journal 18, 6169-6176