New paper on the structural mechanism of helicase loading
Data collected using new Titan Krios cryo-TEM
New paper proposes lagging-strand DNA extrusion mechanism
New cryo-electron microscope produces first beam
London research consortium for cryo-EM awarded £3 million
The London consortium for cryo-EM (LonCEM), of which the The DNA Replication Group is a founding member, awarded £3 million to establish a new, state-of-the-art cryo-EM facility at the Francis Crick Institute. The award is part of a larger £20 million investment by the Wellcome Trust in cryo-electron microscopy to support world-leading structural biologists across the United Kingdom.
Alberto Riera selected for EMBO Practical Course on cryo-EM and 3D imaging
Editorial on pre-RC formation
Riera, A., Li, H., Speck, C. (2013). Seeing is believing: The MCM2–7 helicase trapped in complex with its DNA loader. Cell Cycle 12, 2917-2918.
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New paper establishes architecture of the OCCM complex
Sun, J.*, Evrin, C.*, Samel, S. A., Fernández-Cid, A., Riera, A., Kawakami, H., Stillman, B.†, Speck, C.†, Li, H.† (2013). Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA. Nature Structural & Molecular Biology 20, 944-951.
*Shared first authorship; †Corresponding authors
Abstract | Full text | Brookhaven National Laboratory Newsroom |