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VACANCY: Research associate in genomics (MED02897)

Reference: MED02897 Date posted: 14 December 2021 Closing date: 23 January 2022 Applications are invited for a full-time research associate position in genomics.  This post, funded by a highly competitive Cancer Research UK (CRUK) Discovery Programme Award, aims to uncover mechanisms that guarantee efficient human DNA replication employing genomic approaches.  The project's primary objective is to discover how 1) DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2) DNA replication is regulated to allow faithful DNA replication.  The successful candidate will address how mutations in these processes contribute to genome instability and whether mutations that disrupt these mechanisms are enriched in cancer. Job details | Apply
Featured

VACANCY: Research associate in biochemistry and structural biology (MED02896)

Reference: MED02896 Date posted: 14 December 2021 Closing date: 23 January 2022 Applications are invited for a full-time research associate position in biochemistry and structural biology.  This post, funded by a highly competitive Cancer Research UK (CRUK) Discovery Programme Award, aims to uncover mechanisms that guarantee efficient human DNA replication employing biochemical OR structural approaches.  The project's primary objective is to discover how 1) DNA replication origins are specified through epigenetic mechanisms and specific recruitment factors and 2) DNA replication is regulated to allow faithful DNA replication.  The successful candidate will address how mutations in these processes contribute to genome instability and whether mutations that disrupt these mechanisms are enriched in cancer.  A recently established reconstituted system is available to address these questions for the first time. Job details | Apply

New paper on the molecular mechanism in the licensing of eukaryotic replication origins

Feng, X., Noguchi, Y., Barbon, M., Stillman, B., Speck, C., Li, H. (2021). The structure of ORC-Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6. Nature Communications 12, 3883. Abstract | Full Text |

New paper on the structural mechanism of helicase loading

Yuan, Z., Schneider, S., Dodd, T., Riera, A., Bai, L., Yan, C., Magdalou, I., Ivanov, I., Stillman, B., Li, H., Speck, C. (2020). Structural mechanism of helicase loading onto replication origin DNA by ORC-Cdc6. Proceedings of the National Academy of Sciences of the United States of America 117, 17747-17756. Abstract | Full Text |

Group awarded BBSRC project grant

The Group's Biotechnology and Biological Sciences Research Council (BBSRC) grant application was successful! Huge congratulations to Sarah Schneider, Almutasem Saleh and Yasunori Noguchi for writing a fantastic proposal and achieving a superb ranking of fourth out of 89.  Two new postdoctoral positions will open soon.  Interested candidates should contact Christian Speck.