New paper on activation of the eukaryotic replicative MCM2-7 helicase
Tognetti, S., Riera, A., Speck, C. (2015) Switch on the engine: how the eukaryotic replicative MCM2–7 helicase becomes activated. Chromosoma 124, 13-26.
Abstract |
01Mar2015
20Jan2015
New review paper on the role of MCM2-7 in DNA replication
Riera, A., Speck, C. (2015). MCM2-7 – Opening the gate to DNA Replication. Cell Cycle 14, 6-8.
Full text |
15Oct2014
New paper on Mcm2–7 double-hexamer assembly and function
Sun, J.*, Fernandez-Cid, A.*, Riera, A.*, Tognetti, S., Yuan, Z., Stillman, B.†, Speck, C.†, Li, H.† (2014). Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function. Genes & Development 28, 2291-2303.
*Shared first authorship, †Corresponding authors
Abstract | Biomedical Picture of the Day |
01Aug2014
New paper on regulation of loading of MCM2-7 onto DNA
Samel, S. A., Fernández-Cid, A., Sun, J., Riera, A., Tognetti, S., Herrera, C., Li, H., Speck, C. (2014). A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA. Genes & Development 28, 1653-1666.
Abstract | Imperial College London News |
02May2014
Christian Speck speaks at Wellcome Trust meeting
Christian Speck gives a talk on the key steps in the loading and activation of the replicative helicase MCM2-7 at the Wellcome Trust meeting on Chromatin: From nucleosomes to chromosomes.