Christian Speck selected to the Biochemical Journal editorial board
Christian Speck is selected to the editorial board of the Biochemical Journal. Congratulations, Christian!
23Feb2015
20Jan2015
New review paper on the role of MCM2-7 in DNA replication
Riera, A., Speck, C. (2015). MCM2-7 – Opening the gate to DNA Replication. Cell Cycle 14, 6-8.
Full text |
24Nov2014
New paper on fidelity of the synaptonemal complex assembly
Silva, N., Ferrandiz, N., Barroso, C., Tognetti, S., Lightfoot, J., Telecan, O., Encheva, V., Faull, P., Hanni, S., Furger, A., Snidjers, A. P., Speck, C., Martinez-Perez, E. (2014). The fidelity of synaptonemal complex assembly is regulated by a signaling mechanism that controls early meiotic progression. Developmental Cell 31, 503-511.
Abstract |
15Oct2014
New paper on Mcm2–7 double-hexamer assembly and function
Sun, J.*, Fernandez-Cid, A.*, Riera, A.*, Tognetti, S., Yuan, Z., Stillman, B.†, Speck, C.†, Li, H.† (2014). Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function. Genes & Development 28, 2291-2303.
*Shared first authorship, †Corresponding authors
Abstract | Biomedical Picture of the Day |
29Sep2014
Alberto Riera and Silvia Tognetti’s 3D model of MCM2-7 in BPoD
Alberto Riera and Silvia Tognetti's 3D computer model of MCM2-7 published in BPoD – Biomedical Picture of the Day.
01Aug2014
New paper on regulation of loading of MCM2-7 onto DNA
Samel, S. A., Fernández-Cid, A., Sun, J., Riera, A., Tognetti, S., Herrera, C., Li, H., Speck, C. (2014). A unique DNA entry gate serves for regulated loading of the eukaryotic replicative helicase MCM2–7 onto DNA. Genes & Development 28, 1653-1666.
Abstract | Imperial College London News |
21Jun2014
New paper on the formation of the MCM2-7 double-hexamer
Riera, A., Tognetti, S., Speck, C. (2014). Helicase loading: How to build a MCM2-7 double-hexamer. Seminars in Cell & Developmental Biology 30C, 104-109.
Abstract |
15Sep2013
Editorial on pre-RC formation
Riera, A., Li, H., Speck, C. (2013). Seeing is believing: The MCM2–7 helicase trapped in complex with its DNA loader. Cell Cycle 12, 2917-2918.
Full text |
01Aug2013
New paper establishes architecture of the OCCM complex
Sun, J.*, Evrin, C.*, Samel, S. A., Fernández-Cid, A., Riera, A., Kawakami, H., Stillman, B.†, Speck, C.†, Li, H.† (2013). Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA. Nature Structural & Molecular Biology 20, 944-951.
*Shared first authorship; †Corresponding authors
Abstract | Full text | Brookhaven National Laboratory Newsroom |
15Jul2013
Editorial on the ORC/Cdc6/MCM2–7 complex
Riera, A., Fernández-Cid, A., Speck, C. (2013). The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading. Cell Cycle 12, 2155-2156.
Full text |
23May2013
New paper reveals mechanisms redefining the understanding of DNA licensing
Fernández-Cid, A.*, Riera, A.*, Tognetti, S., Herrera, M. C., Samel, S., Evrin, C., Winkler, C., Gardenal, E., Uhle. S., Speck, C. (2013). An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer formation. Molecular Cell 50, 577-588.
*Shared first authorship
Abstract | Full text | Molecular Cell Preview |
01Mar2013