SpeckLab – Page 8 – Speck Lab / DNA Replication Group

15Jul201315 July 2013

Editorial on the ORC/Cdc6/MCM2–7 complex

Riera, A., Fernández-Cid, A., Speck, C. (2013). The ORC/Cdc6/MCM2–7 complex, a new power player for regulated helicase loading. Cell Cycle 12, 2155-2156.
Full text |

By SpeckLabResearch, Lab Group, Publicationshelicase loading, ORC/Cdc6/MCM2-7 complex0 CommentsRead more...

23May201323 May 2013

New paper reveals mechanisms redefining the understanding of DNA licensing

Fernández-Cid, A.*, Riera, A.*, Tognetti, S., Herrera, M. C., Samel, S., Evrin, C., Winkler, C., Gardenal, E., Uhle. S., Speck, C. (2013). An ORC/Cdc6/MCM2-7 complex is formed in a multistep reaction to serve as a platform for MCM double-hexamer formation. Molecular Cell 50, 577-588.
*Shared first authorship
Abstract | Full text | Molecular Cell Preview |

By SpeckLabLab Group, Publications, ResearchMCM2-7 double hexamer, DNA licensing, ORC/Cdc6/MCM2-7 complex0 CommentsRead more...

01Mar20131 March 2013

New paper on conserved AAA+ motifs within Cdc6 and Orc1 during pre-RC formation

Evrin, C., Fernández-Cid, A., Zech, J., Herrera, M. C., Riera, A., Clarke, P., Brill, S., Lurz, R., Speck, C. (2013). In the absence of ATPase activity, pre-RC formation is blocked prior to MCM2–7 hexamer dimerization. Nucleic Acids Research 41, 3162-3172.
Abstract | Full text |

By SpeckLabPublications, ResearchATPase activity, MCM2-7 hexamers, pre-RC formation, MCM2-7 hexamer dimerization, Cdc6 AAA+ motifs, MCM2-7 recruitment0 CommentsRead more...

07Mar20127 March 2012

New paper on the cryo-EM structures of ORC, ORC-DNA and ORC-Cdc6-DNA

Sun, J., Kawakami, H., Zech, J., Speck, C., Stillman, B., Li, H. (2012). Cdc6-induced conformational changes in ORC bound to origin DNA revealed by cryo-electron microscopy. Structure 20, 534-544.
Abstract | Full text |

By SpeckLabPublications, Research, Lab GroupORC-DNA, ORC-Cdc6-DNA, cryo-EM0 CommentsRead more...

27Apr201127 April 2011

Report on Keystone Symposium on ‘DNA Replication and Recombination’

A report of the Keystone Symposium 'DNA Replication and Recombination' held in Keystone, USA, 27 February to 4 March 2011. Johansson, E., Speck, C. and Chabes, A. (2011). A top-down view on DNA replication and recombination from 9,000 feet above sea level. Genome Biology 12, 304. | Full text |

By SpeckLabPeople, Publications, ResearchDNA replication, Keystone Symposium, DNA recombination0 CommentsRead more...

01Dec20091 December 2009

New paper on double-hexameric MCM2-7 complex loading onto origin DNA

Evrin, C., Clarke, P., Zech, J., Lurz, R., Sun, J., Uhle, S., Li, H., Stillman, B., Speck, C. (2009). A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA. Proceedings of the National Academy of Sciences of the United States of America 106, 20240-20245.
Abstract | Full text | F1000Prime |