Tag - cryo-EM

VACANCY: Research associate in biochemistry (MED01085)

Reference: MED01085
Date posted: 19 February 2019
Closing date: 25 March 2019

This is an ideal opportunity for an enthusiastic and creative scientist to join a dynamic research team with excellent collaborators and facilities. The successful applicant will use cutting-edge biochemical approaches to work on a high profile project investigating novel mechanisms in eukaryotic DNA replication with therapeutic potential.

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New paper proposes lagging-strand DNA extrusion mechanism

Noguchi, Y., Yuan, Z., Bai, L., Schneider, S., Zhao, G., Stillman, B., Speck, C., Li, H. (2017). Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. Proceedings of the National Academy of Sciences of the United States of America 114, E9529-E9538.
Abstract | Full text |

New cryo-electron microscope produces first beam

The cryo-electron microscope installed on the Imperial College London Hammersmith Campus produces its first beam, coinciding, fittingly, with the award of the 2017 Nobel Prize in Chemistry, to Jacques Dubochet, Joachim Franck and Richard Henderson, “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution.”

London research consortium for cryo-EM awarded £3 million

The London consortium for cryo-EM (LonCEM), of which the The DNA Replication Group is a founding member, awarded £3 million to establish a new, state-of-the-art cryo-EM facility at the Francis Crick Institute. The award is part of a larger £20 million investment by the Wellcome Trust in cryo-electron microscopy to support world-leading structural biologists across the United Kingdom.

New paper establishes architecture of the OCCM complex

Sun, J.*, Evrin, C.*, Samel, S. A., Fernández-Cid, A., Riera, A., Kawakami, H., Stillman, B.†, Speck, C.†, Li, H.† (2013). Cryo-EM structure of a helicase loading intermediate containing ORC–Cdc6–Cdt1–MCM2-7 bound to DNA. Nature Structural & Molecular Biology 20, 944-951.
*Shared first authorship; †Corresponding authors
Abstract | Full text | Brookhaven National Laboratory Newsroom |