Author - SpeckLab

VACANCY: Research associate in biochemistry (human replication) (MED00186)

Reference: MED00740
Date posted: 31 August 2018
Closing date: 07 October 2018

This is an ideal opportunity for an enthusiastic and highly creative scientist to join a dynamic research team with excellent collaborators and facilities. The successful applicant will use cutting-edge cryo-EM approaches to discover protein structures of key DNA replication complexes. This work will help to identify novel mechanism in DNA replication, which can be targeted in the future for the development of small molecule inhibitors with therapeutic potential.

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New paper proposes lagging-strand DNA extrusion mechanism

Noguchi, Y., Yuan, Z., Bai, L., Schneider, S., Zhao, G., Stillman, B., Speck, C., Li, H. (2017). Cryo-EM structure of Mcm2-7 double hexamer on DNA suggests a lagging-strand DNA extrusion model. Proceedings of the National Academy of Sciences of the United States of America 114, E9529-E9538.
Abstract | Full text |

New cryo-electron microscope produces first beam

The cryo-electron microscope installed on the Imperial College London Hammersmith Campus produces its first beam, coinciding, fittingly, with the award of the 2017 Nobel Prize in Chemistry, to Jacques Dubochet, Joachim Franck and Richard Henderson, “for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution.”