Headed by Christian Speck, the DNA Replication Group was established in 2006 with the aim of discovering new mechanisms in the initiation and elongation of DNA replication and to understand the function of replication factors in hetero-chromatin formation.

Group News

VACANCY: Research technician (MED00232)

Reference: MED00232 Date posted: 19 January 2018 Closing date: 11 February 2018 This is an exciting opportunity to join a group of... read more

VACANCY: Research associate in biochemistry (human replication) (MED00186)

Reference: MED00186 Date posted: 20 December 2017 Closing date: 21 January 2018 This is an ideal opportunity for an enthusiastic and highly... read more

VACANCY: Research associate in biochemistry (yeast replication) (MED00185)

Reference: MED00185 Date posted: 20 December 2017 Closing date: 21 January 2018 This is an ideal opportunity for an enthusiastic and creative... read more

Sarah Schneider awarded DFG Research Fellowship

Sarah Schneider awarded a prestigious two year Deutsche Forschungsgemeinschaft (DFG) Research Fellowship.  Congratulations Sarah! read more

Athena SWAN Silver Department Award

The MRC London Institute of Medical Sciences (LMS) and Imperial College London Institute of Clinical Sciences receive an Athena... read more

New paper proposes lagging-strand DNA extrusion mechanism

Noguchi, Y., Yuan, Z., Bai, L., Schneider, S., Zhao, G., Stillman, B., Speck, C., Li, H. (2017). Cryo-EM structure... read more

Katalin Kondas selected for the 2017 EMBL-EBI course in Structural Bioinformatics

Katalin Kondas selected to participate in the 2017 European Bioinformatics Institute (EMBL-EBI) course in Structural Bioinformatics, 23 – 27 October... read more

Yasunori Noguchi awarded JSPS Overseas Research Fellowship

Yasunori Noguchi awarded a prestigious two year Japan Society for the Promotion of Science (JSPS) Overseas Research Fellowship.  Congratulations... read more

New cryo-electron microscope produces first beam

The cryo-electron microscope installed on the Imperial College London Hammersmith Campus produces its first beam, coinciding, fittingly, with the... read more

Chris Weekes joins the Group

Chris Weekes joins the Group as a PhD student.  Welcome Chris! read more

Katalin Kondas participates in EMBO Practical Course

As a selected participant, Katalin Kondas attends the EMBO Practical Course “High-throughput protein production and crystallization”, 6 – 14 July... read more

MRC Festival of Medical Science

Indiana Magdalou, Sarah Schneider and Christian Speck speak to local A-level students at the MRC Festival of Medical Science... read more

Group Milestones


Nature Structure & Molecular Biology 24, 316-324
Elucidation of the structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1


Genes & Development 28, 2291-2303
Elucidation of the MCM2-7 double-hexamer structure reveals key mechanism in helicase loading and activation

Genes & Development 28, 1653-1666
Identification of the DNA entry gate of the MCM2-7 helicase during helicase loading


Nature Structural & Molecular Biology 20, 944-951
Characterisation of the first structure of an eukaryotic replicative helicase in complex with its loading factors

Molecular Cell 50, 577-588
Identification of a novel ATPase dependent pre-RC intermediate that is surveyed by a quality control mechanism for genomic stability

Nucleic Acids Research 41, 3162-3172
Discovery of a pre-RC intermediate that forms in the absence of ATP-hydrolysis and contains one copy of all 18 pre-RC factors


PNAS 106, 20240-20245
Reconstitution of pre-RC formation and discovery of the MCM2-7 double-hexamer as a central DNA replication intermediate


The Journal of Biological Chemistry 282, 11705-11714
Identification of an ATPase-dependent mechanism that allows sequence specific recognition of the DNA replication origin


Nature Structural & Molecular Biology 12, 965-971
Elucidation of the ORC-Cdc6 complex structure and its sequence specific origin binding activity


The EMBO Journal 20, 1469-1476
Identification of key mechanism in initiation of DNA replication in bacteria


The EMBO Journal 18, 6169-6176
Discovery of an ATP dependent mechanism to coordinate initiation of DNA replication with transcriptional regulation in bacteria