Headed by Christian Speck, the DNA Replication Group was established in 2006 with the aim of discovering new mechanisms in the initiation and elongation of DNA replication and to understand the function of replication factors in hetero-chromatin formation.

Group News

VACANCY: LMS 3.5 Year Studentship

A 3.5 year fully-funded studentship is available for a talented and highly-motivated graduate student with good knowledge of biochemical... read more

VACANCY: Research associate in biochemistry (HM2017034)

A three year postdoctoral research associate position is available for an outstanding biochemist or molecular biologist to use cutting-edge biochemical... read more

Leonhard Karl joins the Group

Leonhard Karl joins the Group as a MSc student. Welcome, Leonhard! read more

London research consortium for cryo-EM awarded £3 million

The London consortium for cryo-EM (LonCEM), of which the The DNA Replication Group is a founding member, awarded £3 million to... read more

New paper on MCM2-7 replicative helicase loading

Yuan, Z., Riera, A., Bai, L., Sun, J., Nandi, S., Spanos, C., Chen, Z. A., Barbon, M., Rappsilber, J.,... read more

Max Reuter awarded DFG Research Fellowship

Max Reuter awarded a prestigious two year Deutsche Forschungsgemeinschaft (DFG) Research Fellowship.  Congratulations Max! read more

Indiana Magdalou receives CSC Local Hero Award

Indiana Magdalou receives a CSC Local Hero Award following her nomination for her contribution to the Institute of Clinical... read more

Katalin Kondas joins the Group

Katalin Kondas joins the Group as a Daphne Jackson Fellow sponsored by the Biotechnology and Biological Sciences Research Council... read more

Group Milestones

2017

Nature Structure & Molecular Biology 24, 316-324
Elucidation of the structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1

2014

Genes & Development 28, 2291-2303
Elucidation of the MCM2-7 double-hexamer structure reveals key mechanism in helicase loading and activation


Genes & Development 28, 1653-1666
Identification of the DNA entry gate of the MCM2-7 helicase during helicase loading

2013

Nature Structural & Molecular Biology 20, 944-951
Characterisation of the first structure of an eukaryotic replicative helicase in complex with its loading factors


Molecular Cell 50, 577-588
Identification of a novel ATPase dependent pre-RC intermediate that is surveyed by a quality control mechanism for genomic stability


Nucleic Acids Research 41, 3162-3172
Discovery of a pre-RC intermediate that forms in the absence of ATP-hydrolysis and contains one copy of all 18 pre-RC factors

2009

PNAS 106, 20240-20245
Reconstitution of pre-RC formation and discovery of the MCM2-7 double-hexamer as a central DNA replication intermediate

2007

The Journal of Biological Chemistry 282, 11705-11714
Identification of an ATPase-dependent mechanism that allows sequence specific recognition of the DNA replication origin

2005

Nature Structural & Molecular Biology 12, 965-971
Elucidation of the ORC-Cdc6 complex structure and its sequence specific origin binding activity

2001

The EMBO Journal 20, 1469-1476
Identification of key mechanism in initiation of DNA replication in bacteria

1999

The EMBO Journal 18, 6169-6176
Discovery of an ATP dependent mechanism to coordinate initiation of DNA replication with transcriptional regulation in bacteria