Headed by Christian Speck, the DNA Replication Group was established in 2006 with the aim of discovering new mechanisms in the initiation and elongation of DNA replication and to understand the function of replication factors in hetero-chromatin formation.

Group News

VACANCY: Research associate in biochemistry (MED01085)

Reference: MED01085 Date posted: 19 February 2019 Closing date: 25 March 2019 This is an ideal opportunity for an enthusiastic and creative... read more

Almutasem Saleh joins the Group

Almutasem Saleh joins the Group as a research associate.  Welcome Al! read more

Marta Barbon defends PhD thesis

Marta Barbon defends her PhD thesis.  Congratulations, Marta! read more

Adrian Söderholm joins the Group

Adrian Söderholm joins the Group as a MRes student.  Välkommen, Adrian! read more

Cecilia Pennica joins the Group

Cecilia Pennica joins the Group as a postdoctoral fellow. Welcome, Cecilia! read more

Vera Leber joins the Group

Vera Leber joins the Group as a postdoctoral fellow. Welcome, Vera! read more

Owen Burbidge joins the Group

Owen Burbidge joins the Group as a senior biochemical research scientist. Welcome, Owen! read more

The Group awarded BBSRC project grant

Sarah Schneider and Christian Speck successfully applied for a Biotechnology and Biological Sciences Research Council (BBSRC) project grant to... read more

Marta Barbon awarded Biochemical Society Sponsored Events Grant

Marta Barbon awarded a Biochemical Society Sponsored Events Grant to support the Biochemistry Club.  Well done, Marta! read more

Sarah Schneider awarded DFG Research Fellowship

Sarah Schneider awarded a prestigious two year Deutsche Forschungsgemeinschaft (DFG) Research Fellowship.  Congratulations, Sarah! read more

Athena SWAN Silver Department Award

The MRC London Institute of Medical Sciences (LMS) and Imperial College London Institute of Clinical Sciences receive an Athena... read more

New paper proposes lagging-strand DNA extrusion mechanism

Noguchi, Y., Yuan, Z., Bai, L., Schneider, S., Zhao, G., Stillman, B., Speck, C., Li, H. (2017). Cryo-EM structure... read more

Group Milestones


Nature Structure & Molecular Biology 24, 316-324
Elucidation of the structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1


Genes & Development 28, 2291-2303
Elucidation of the MCM2-7 double-hexamer structure reveals key mechanism in helicase loading and activation

Genes & Development 28, 1653-1666
Identification of the DNA entry gate of the MCM2-7 helicase during helicase loading


Nature Structural & Molecular Biology 20, 944-951
Characterisation of the first structure of an eukaryotic replicative helicase in complex with its loading factors

Molecular Cell 50, 577-588
Identification of a novel ATPase dependent pre-RC intermediate that is surveyed by a quality control mechanism for genomic stability

Nucleic Acids Research 41, 3162-3172
Discovery of a pre-RC intermediate that forms in the absence of ATP-hydrolysis and contains one copy of all 18 pre-RC factors


PNAS 106, 20240-20245
Reconstitution of pre-RC formation and discovery of the MCM2-7 double-hexamer as a central DNA replication intermediate


The Journal of Biological Chemistry 282, 11705-11714
Identification of an ATPase-dependent mechanism that allows sequence specific recognition of the DNA replication origin


Nature Structural & Molecular Biology 12, 965-971
Elucidation of the ORC-Cdc6 complex structure and its sequence specific origin binding activity


The EMBO Journal 20, 1469-1476
Identification of key mechanism in initiation of DNA replication in bacteria


The EMBO Journal 18, 6169-6176
Discovery of an ATP dependent mechanism to coordinate initiation of DNA replication with transcriptional regulation in bacteria