Headed by Christian Speck, the DNA Replication Group was established in 2006 with the aim of discovering new mechanisms in the initiation and elongation of DNA replication and to understand the function of replication factors in hetero-chromatin formation.

Group News

Shenaz Allyjaun and Jessica Ellins join the Group

Shenaz Allyjaun and Jessica Ellins join the Group as PhD students.  Welcome Shenaz and Jessica! read more

Joseph Dobbs joins the Group

Joseph Dobbs, a BSc student in Biochemistry and Microbiology at the University of Victoria, Canada, joins the Group as... read more

Greta Baltušytė joins the Group

Greta Baltušytė, a bachelor’s student in the Natural Sciences at the University of Cambridge, UK,  joins the Group as... read more

Halil Bounoua joins the Group

Halil Bounoua, a biology student at biology at ENS Lyon, France, joins the Group as an undergraduate intern.  Bienvenue... read more

Sarah Faull joins the Group

Sarah Faull joins the Group as a postdoctoral fellow.  Welcome Sarah! read more

Jillian Tay joins the Group

Jillian Tay joins the Group as a MRes student.  Welcome Jillian! read more

Megan Turner joins the Group

Megan Turner joins the Group as a MSc student.  Welcome Megan! read more

Audrey Mossler joins the Group

Audrey Mossler joins the Group to gain research experience in a UK laboratory. Bienvenue Audrey! read more

Almutasem Saleh joins the Group

Almutasem Saleh joins the Group as a postdoctoral fellow.  Welcome Al! read more

Marta Barbon defends PhD thesis

Marta Barbon defends her PhD thesis.  Congratulations, Marta! read more

Adrian Söderholm joins the Group

Adrian Söderholm joins the Group as a MRes student.  Välkommen, Adrian! read more

Cecilia Pennica joins the Group

Cecilia Pennica joins the Group as a postdoctoral fellow. Welcome, Cecilia! read more

Group Milestones

2017

Nature Structure & Molecular Biology 24, 316-324
Elucidation of the structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1

2014

Genes & Development 28, 2291-2303
Elucidation of the MCM2-7 double-hexamer structure reveals key mechanism in helicase loading and activation


Genes & Development 28, 1653-1666
Identification of the DNA entry gate of the MCM2-7 helicase during helicase loading

2013

Nature Structural & Molecular Biology 20, 944-951
Characterisation of the first structure of an eukaryotic replicative helicase in complex with its loading factors


Molecular Cell 50, 577-588
Identification of a novel ATPase dependent pre-RC intermediate that is surveyed by a quality control mechanism for genomic stability


Nucleic Acids Research 41, 3162-3172
Discovery of a pre-RC intermediate that forms in the absence of ATP-hydrolysis and contains one copy of all 18 pre-RC factors

2009

PNAS 106, 20240-20245
Reconstitution of pre-RC formation and discovery of the MCM2-7 double-hexamer as a central DNA replication intermediate

2007

The Journal of Biological Chemistry 282, 11705-11714
Identification of an ATPase-dependent mechanism that allows sequence specific recognition of the DNA replication origin

2005

Nature Structural & Molecular Biology 12, 965-971
Elucidation of the ORC-Cdc6 complex structure and its sequence specific origin binding activity

2001

The EMBO Journal 20, 1469-1476
Identification of key mechanism in initiation of DNA replication in bacteria

1999

The EMBO Journal 18, 6169-6176
Discovery of an ATP dependent mechanism to coordinate initiation of DNA replication with transcriptional regulation in bacteria